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Quattroflow

Quattroflow develops and manufactures single use diaphragm pumps for critical applications in the biopharmaceutical industry.

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Founded in 2000, Quattroflow was acquired by PSG, a Dover company, in 2011 and moved into the Almatec production facility in Kamp-Lintfort, Germany. In 2018, Quattroflow and Almatec moved to a new corporate headquarters in Duisburg, Germany, giving the two growing companies approximately 70% more space, including a much larger production facility and an advanced ISO Class 7 cleanroom.

Quattroflow quaternary diaphragm pumps are truly unique in that their method of operation mimics the human heart, which is the perfect model for safe, reliable and efficient transfer of biological materials.

The four-piston design does not include a mechanical shaft seal or wetted rotating parts, ensuring total product containment without wear. In addition, the four-piston pump principle enables risk-free dry running, low pulsation, self-priming function and minimal particle generation.

Quattroflow pumps are available with reusable stainless steel pump chambers that can be cleaned or disposable pump chambers for single-use applications.

Quattroflow's single-use pumps are equipped with a product-wetted plastic pump chamber that can be replaced as a complete single-use unit. This simple design feature creates a faster production process while saving time and money by eliminating the need for complex sterilisation and cleaning validation.

Quattroflow disposable pumps also deliver the required levels of product purity and sterility that these applications demand, eliminating the chance of damaging the product and reducing the likelihood of expensive contamination across batches or across products.

In addition, disposable pumps reduce downtime between batches and are quick and easy to change. A disposable pump chamber can be replaced in less than a minute and their simple design requires only a single tool. Using the EZ-Set replacement system, the pump chamber can be changed manually. The simple disposal of the pump chamber saves time and money by reducing downtime for cleaning, sterilisation and complex cleaning validation.

With an operation that offers low friction, low shear and low pulsation, Quattroflow pumps are ideal for critical biopharma manufacturing applications including Tangential Flow Filtration (TFF), Chromatography (RFC), centrifuge feeding, sterile virus filtration, purification and inline dilution.

Suitable for CIP/SIP, the pumps increase flexibility, reduce downtime, eliminate cleaning validation costs and cross-contamination risks.

Using Quattroflow single use pumps provides a faster production process while meeting the required levels of product purity and sterility with no damage to the product and no risk of cross-contamination.